■原著：

1. Nagao T, Kazunori T, Kitagawa K, Kitazono T, Yamagami H, Uchiyama S, Tanahashi N, Matsumoto M, Minematsu K, Nagata I, Nishikawa M, Nanto S, Abe K, Ikeda Y, Ogawa A: A noninferiority confirmatory trial of prasugrel versus clopidogrel in Japanese patients with non-cardioembolic stroke: rationale and study design for a randomized controlled trial – PRASTRO-I trial. Expert Opin Pharmacother2018.2 Epub.

2. Nagao T, Kodani E: Novel Therapeutic Target of Anticoagulation Therapy in Patients With Atrial Fibrillation- Cognitive Decline and Dementia. Circ J2018.2（82）644-655.

3. Abe, A, Sakamoto Y, Nishiyama Y, Suda S, Suzuki K, Aoki J, Kimura K: Decline in Hemoglobin during Hospitalization May Be Associated with Poor Outcome in Acute Stroke Patients. Journal of Stroke and Cerebrovascular Diseases, 2018；27（6）：1646-1652.

4. Suda S, Aoki J, Shimoyama T, Suzuki K, Sakamoto Y, Katano T, Okubo S, Nito C, Nishiyama Y, Mishina M, Kimura K: Low Free Triiodothyronine at Admission Predicts Poststroke Infection. J Stroke Cerebrovasc Dis 2018；27（2）：397-403.

5. Omura T, Kimura M, Kim K, Mishina M, Mizunari T, Kobayashi S, Morita A: Acute Poststroke Depression Is Associated with Thalamic Lesions and Clinical Outcomes: A Case-Control Study. J Stroke Cerebrovasc Dis 2018；27（2）：499-505.

6. Suda S, Aoki J, Shimoyama T, Suzuki K, Sakamoto Y, Katano T, Okubo S, Nito C, Nishiyama Y, Mishina M, Kimura K: Stroke-associated infection independently predicts 3-month poor functional outcome and mortality. J Neurol 2018；265（2）：370-375.

7. Houkin K, Shichinohe H, Abe K, Arato T, Dezawa M, Honmou O, Horie N, Katayama Y, Kudo K, Kuroda S, Matsuyama T, Miyai I, Nagata I, Niizuma K, Sakushima K,Sasaki M, Sato N, Sawanobori K, Suda S, Taguchi A, Tominaga T, Yamamoto H,Yamashita T, Yoshimine T; Working Group for Guidelines on Development of Cell-Based Products for the Treatment of Cerebral Infarction. Accelerating Cell Therapy for Stroke in Japan: Regulatory Framework and Guidelines on Development of Cell-Based Products.Stroke. 2018；49（4）：e145-e152.

8. Ota T, Nishiyama Y, Koizumi S, Saito T, Ueda M, Saito N. Impact of onset-to-groin puncture time within three hours on functional outcomes in mechanical thrombectomy for acute large-vessel occlusion. Interv Neuroradiol. 2018；24（2）：162-167.

9. Kashimura M, Nomura T, Ishiwata A, Kitamura S, Feasibility of applying the psychosocial intervention Strategies for Relatives to family caregivers of patients with dementia: a case report. Psychogeriatrics.2018 Feb 11. doi: 10.1111/psyg.12315.

10. Nagayama H, Maeda T, Uchiyama T, Hashimoto M, Nomoto N, Kano O, Takahashi T, Terashi H, Hamada S, Hasegawa T, Hatano T, Takahashi T, Baba Y, Sengoku R, Watanabe H, Inoue M, Kadowaki T, Kaneko S,Shimura H, Kubo SI; Young Japanese Expert Group for Parkinson’s Disease and Movement Disorders: YJEXPANDS:Anhedonia and its correlation with clinical aspects in Parkinson’s disease. J Neurol Sci 2017；372：403-407.

11. Kanamaru T, Suda S, Muraga K, Okubo S, Watanabe Y, Tsuruoka S, Kimura K: Albuminuria predicts early neurological deterioration in patients with acute ischemic stroke. Journal of the Neurological Sciences 2017；372：417-420.

12. Sakamoto Y, Shimizu T, Tobisawa S, Isozaki E: Chronic demyelinating neuropathy with anti-myelinassociated glycoprotein antibody without any detectable M-protein. Neurological Sciences 2017；38（12）：2165-2169.

13. Sakamoto Y, Okubo S, Nito C, Suda S, Matsumoto N, Abe A, Aoki J, Shimoyama T, Muraga K, Kanamaru T,Suzuki K, Go Y, Mishina M, Kimura K: The Prevalence of and Factors Related to Vascular Hyperintensity on T1-Weighted Imaging in Acute Ischemic Stroke. Cerebrovascular Disease 2017；44（3-4）：203-209.

14. Sakamoto Y, Shimizu T, Tobisawa S, Isozaki E: Prevalence and clinical characteristics of corticobasal syndrome with an initial symptom outside of the upper limb. Neurological Sciences. 2017；38（5）：783-787.

15. Mishina M, Ishii K, Kimura Y, Suzuki M, Kitamura S, Ishibashi K, Sakata M, Oda K, Kobayashi S, Kimura K, Ishiwata K: Adenosine A1 receptors measured with 11C-MPDX PET in early Parkinson’s disease.Synapse 2017；71（8）：e21979.

16. Suda S, Shimoyama T, Suzuki S, Ouchi T, Arakawa M, Aoki J, Suzuki K, Sakamoto Y, Okubo S, Nishiyama Y, Nito C, Mishina M, Kimura K: Prevalence and clinical characteristics of cortical superficial siderosis in patients with acute stroke. J Neurol 2017；264（12）：2413-2419.

17. Sakamoto Y, Okubo S, Nito C, Suda S, Matsumoto N, Abe A, Aoki J, Shimoyama T, Takayama Y, Suzuki K, Mishina M, Kimura K: The relationship between stroke severity and prior direct oral anticoagulant therapy in patients with acute ischaemic stroke and non-valvular atrial fibrillation. Eur J Neurol 2017；24（11）：1399-1406.

18. Mishina M, Kimura Y, Sakata M, Ishii K, Oda K, Toyohara J, Kimura K and Ishiwata K: Age-Related Decrease in Male Extra-Striatal Adenosine A1 Receptors Measured using 11C-MPDX PET. Front Pharmacol 2017；8（12）：Article 903.

19. Abe K, Aoki M, Tsuji S, Itoyama Y, Sobue G, Togo M, Hamada C, Tanaka M, Akimoto M, Nakamura K,Takahashi F, Kondo K, Yoshino H, Sasaki H, Yabe I, Doi S, Warita H, Imai T, Ito H, Fukuchi M, Osumi E,Wada M, Nakano I, Morita M, Ogata K, Maruki Y, Ito K, Kano O, Yamazaki M, Takahashi Y, Ishiura H,Ogino M, Koike R, Ishida C, Uchiyama T, Mizoguchi K, Obi T, Watanabe H, Atsuta N, Aiba I, Taniguchi A,Sawada H, Hazama T. : Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial The Lancet Neurology. 2017；16（7）：505-512.

20. Abe K, Aoki M, Tsuji S, Itoyama Y, Sobue G, Togo M, Hamada C, Sasaki H, Yabe I, Doi S, Warita H, Imai T,Ito H, Fukuchi M, Osumi E, Wada M, Nakanoy I, Morita M, Ogata K, Maruki Y, Ito K, Kano O, Yamazaki M,Takahashi Y, Ishiura H, Koike R, Ishida C, Uchiyama T, Mizoguchi K, Obi T, Watanabe H, Atsuta N, Aiba I, Taniguchi A, Sawada H, Hazama T, Fujimura H, Kusaka H, Kunieda T, Kikuchi H, Matsuo H, Ueyama H, Uekawa K, Tanaka M, Akimoto M, Nakamura K, Ueda M, Kotani K, Matsui H, Yoneoka T, Morimoto K,Sasaki K, Hirai M, Murakami A, Natori T, Sumii R, Terai H, Kudou T, Takahashi F, Iwasaki T, Kondo K,Yoshino H: Open-label 24-week extension study of edaravone （MCI-186） in amyotrophic lateral sclerosis.Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration2017；18（10）：55-63.

21. Abe K, Itoyama Y, Tsuji S, Sobue G, Aoki M, Doyu M, Hamada C, Sasaki H, Takei A, Yamashita I, Imai T, Nakano I, Okamoto K, Maruki Y, Mishima S, Nishimiya J, Iwasaki Y, Yamazaki M, Takahashi Y, Ogino M, Ogino Y, Ogawa M, Kamei T, Uchiyama T, Watanabe H, Kokubo Y, Sawada H, Hazama T, Kimura F, Fujimura H, Kusaka H, Hashimoto T, Yamada T, Kanamori Y, Yamasaki K, Kaku S, Kikuchi H, Imamura S, Sugimoto S, Kishi M, Tanaka M, Akimoto M, Nakamura K, Naito H, Murakami A, Sakamoto H, Yoneoka T, Enjoji K, Ogawa J, Yano K, Yashiro M, Hirai M, Furuta K, Sasaki K, Shiide Y, Takayanagi G, Takahashi F, Iwasaki T, Kondo K, Yoshino H: Exploratory double-blind, parallel-group, placebo-controlled extension study of edaravone （MCI-186） in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration2017；18（10）：20-31.

22. Nakajima M, Nito C, Sowa K, Suda S, Nishiyama Y, Nakamura-Takahashi A, Nitahara-Kasahara Y,Imagawa K, Hirato T, Ueda M, Kimura K, Okada T:Mesenchymal stem cells overexpressing interleukin-10 promote neuroprotection in experimental acute ischemic stroke. Molecular therapy. Methods & clinical development. 2017；6：102-111.

23. Suda S, Kanamaru T, Okubo S, Aoki J, Shimoyama T, Suzuki K, Nito C, Ishiwata A, Kimura K. Urinary albumin-to-creatinine ratio is associated with white matter lesions severity in first-ever stroke patients. Journal of the neurological sciences. 2017；373：258-262.

24. Takuma A, Abe A, Saito Y, Nito C, Ueda M, Ishimaru Y, Harada H, Abe K, Kimura K, Asakura T. Gene expression analysis of the effect of ischemic infarction in whole blood. Int J Mol Sci. 2017；18（11）：E2335.

25. Katayama Y, Inaba T, Nito C, Suda S, Ueda M. Neuroprotective effects of clarithromycin against neuronal damage in cerebral ischemia and in cultured neuronal cells after oxygen-glucose deprivation. Life Sci.2017；168： 7-15.

26. Nagai K, Aoki J, Sakamoto Y, Kimura K: About 30% of wake-up stroke patients may be candidate for the t-PA therapy using Negative-FLAIR as a“ tissue clock”. Journal of the Neurological Sciences 2017；382：101-104.

27. Suzuki K, Aoki J, Sakamoto Y, Abe A, Suda S, Okubo S, Nagao T, Kimura K. Low risk of ICH after reperfusion therapy in acute stroke patients treated with direct oral anti-coagulant. J Neurol Sci. 2017 Aug 15；379：207-211.

28. Takahashi S, Tanizaki Y, Akaji K, Kimura H, Katano T, Suzuki K, Mochizuki Y, Shidoh S, Nakazawa M,Yoshida K, Mihara B. Identification of hemodynamically compromised regions by means of cerebral blood volume mapping utilizing computed tomography perfusion imaging. J Clin Neurosci. 2017 Apr；38：74-78.

29. Nagao T, Naganuma M, Shiga T, Suzuki A, Murasaki K, Hagiwara N: Effectiveness and safety of dabigatran versus warfarin in “real-world” Japanese patients with atrial fibrillation: A single-center observational study. J Arrhythm 2017.4（33）107-110.

■症例報告：

1. Abe A, Sekine T, Sakamoto Y, Harada-Abe M, Takagi R, Suda S, Aoki J, Yoneyama M, Kimura K:Contrast-Enhanced High-Resolution MRI for Evaluating Time Course Changes in Middle Cerebral Artery Plaques. Journal of Nippon Medical School 2018；85（1）：28-33.

2. Abe A, Sakamoto Y, Nishiyama Y, Suda S, Suzuki K, Aoki J, Kimura K: Decline in Hemoglobin during Hospitalization May Be Associated with Poor Outcome in Acute Stroke Patients. Journal of Stroke and Cerebrovascular Diseases, 2018, 27（6）：1646-1652.

3. Taluma A, Abe A, Saito Y, Nito C, Ueda M, Ishimaru Y, Harada H, Abe K, Kimura K and Asakura, T: Gene Expression Analysis of the Effect of Ischemic Infarction in Whole Blood. International journal of molecular sciences, 2017, 18（11）：2335.

4. Kinjo Y, Suda S, Sakamoto Y, Okubo S, Kimura K: Ataxic Hemiparesis Associated with Cortical Infarct Localized in the Postcentral Gyrus. Internal Medicine 2017；56（18）：2503-2505.